Robert F. Conkling | Thursday, 14 January 2010
tags : cancer, contraception, pollution, sti's Medication that makes you sick When will the health establishment acknowledge the well being hazards associated with chemical contraceptives?
Not long ago 3 main health tales appeared from the Washington press in lower than two weeks that were an event to pause and reflect.
Very first, the Potomac Conservancy created headlines in regards to the contamination of rivers and drinking water in key metropolitan areas, including Washington DC. Contaminants consist of not simply bacteria, industrial chemical substances and agricultural pesticides but also potentially endocrine-active pharmaceuticals, this sort of anti-depressants, contraceptive intercourse hormones, antibiotics and private treatment products.
Next came the report of US Preventive Companies Process Power, an independent physique which reports mortality from widespread illnesses, issuing new recommendations for mammographic screening for early detection of breast cancer. Breast Cancer continues to be the second greatest cause of mortality of American females because it began to rise in the 1970s.
Finally, the Centers for Disease Manage (CDC) documented the yearly stats for ######ually transmitted conditions. In 2008 there was a document range of new circumstances of Chlamydia -- a whopping 1.2 million new circumstances, a rise from the quantity of new cases of syphilis and an all-time file of 19 million total circumstances of all kinds of STDs.
To link the dots among these tales one needs to ask: Could steroid–based intercourse hormone contraceptives be a widespread thread?
Hard to believe until you consider the evidence.
A pill is born
The 1st ###### hormone-containing pill, a synthetic steroid called Norethindrone,
Office 2010 Activation Key, was developed by organic chemist Carl Djerassi in Syntex Laboratories in Mexico City. Djerassi was developing a synthetic progestin for menstrual irregularities. His product turned out to be a powerful inhibitor of ovulation, but he had not anticipated that the estrogen-with-progestin combination oral birth management pill (COCP) would have other effects upon women. Only after many years was this combination suspected as the culprit in many unexpected side-effects, including blood clots, diabetes, depression or anxious emotional states experienced by ladies.
That some of these side-effects can be serious is confirmed by a new report of conclusive evidence for significant loss of bone mineral density when a woman uses Depo-Provera (a long acting injectable form of progestin-only contraceptive) for more than two years.
In 2005 the International Agency for Research on Cancer Research (IARC), an arm of the World Well being Organization, estimated that worldwide more than 100 million girls had been using some form of COCP. In developed countries, the current usage was estimated at 16 percent, while the “ever used” rate was as high as 80 percent. While there appeared to be extreme variability in between countries, the evaluation found that most contraceptives were used by girls of younger age and with higher educational achievement.
After an earlier evaluation the IARC had classified oral contraceptives as a Group one carcinogen: “There is sufficient evidence in humans for the carcinogenicity of combined oral estrogen-progestogen contraceptives,” it said in 1999. The weight of evidence indicated an increased risk of breast cancer which was greater for women who have been under age 35 at the time of diagnosis and who had begun using contraceptives before their 20th birthday. This was reaffirmed by the 2005 review.
In 2006 the Mayo Clinic Proceedings published a meta-analysis of 23 scientific studies done in several countries about breast cancer risk and usage of oral contraceptives. Dr Chris Kahlenborn, one particular of the principal authors, stated that “if a woman takes combined oral contraceptive pills before her first full term pregnancy, she hazards a 44 percent increased chance of developing pre-menopause breast cancer when compared to females who have never taken an OCP”. Kahlenborn also found that “if a woman takes OCPs for 4 years or more prior to her 1st full term pregnancy, she suffers a 52 percent increased risk”.
Kahlenborn also uncovered that the commonly used contraceptive Depo-Provera was reported by the WHO and a New Zealand study to be connected with a statistically significant 190 percent increased risk of breast cancer when Depo-Provera was taken by a woman for more than 3 years prior to the age of 25 years.
Drinking water contamination
In 2002 the US Geological Survey found one particular or more pharmaceuticals in 80 percent of the streams it had tested. In 2006 the Los Angeles Times reported that sewage contains traces of medications like antibiotics, anti-depressants, birth-control hormones, Viagra, Valium and heart drugs. Shane Snyder, lead toxicologist at the Southern Nevada Water Authority, said: “there is no place on Earth exempted from having pharmaceuticals and steroids in its wastewater. This is clearly an issue that is global, and we are going to see more and more of these chemicals from the environment, no doubt about it.”
The Potomac Conservancy found similar consuming h2o conditions in Washington DC. Mirroring other regions of the country where biologists have found frogs contaminated with Prozac, insects on anti-seizure drugs and algae killed by antibiotics, the waterways draining the Shenandoah Mountains and tributaries flowing into the Potomac River have witnessed fish kills given that 2002. The unexpected observation was that most of the dead male fish had inter-###### characteristics and that there was a disproportionate amount of female fish. Further examination by the US Geological Survey of the Potomac tributaries revealed that 80 percent of the male fish had the inter-###### condition.
While the concentrations of some of the pharmaceuticals found in consuming water sources, including estrogens and fertility drugs, are inside the parts per trillion, comparable to putting a few drops in an Olympic-sized pool, the effects this may have on humans stays unknown. What is known is that on the level of endocrine systems, fish and humans function in very similar ways. What happens to fish may be signaling future disorders for humans.
Contraceptives: a form of endocrine disrupting chemical compounds
In 2009 the world’s leading professional association for endocrinologists, the Endocrine Society, issued a strong statement on endocrine-disrupting chemical substances. The evidence suggests that exposure to multiple endocrine disrupting chemicals at developmental stages has the potential to affect any hormone-sensitive system system, including the breast and the hypothalamic-pituitary-ovarian system in women, and the testes and prostate gland in men. The Endocrine Society appealed to the precautionary principle stating: “This principle is key to enhancing endocrine and reproductive wellness, and should be consulted to inform decisions about exposure to and risk from any potential endocrine disruptor.” And: “The public may be placed at risk because critical information about potential health effects of endocrine disrupting chemical compounds to which Americans are exposed is being overlooked from the development of federal guidelines and regulations.”
The pill’s link to STDs
Are there any strong associations amongst use of steroid-based OCPs and ######ually transmitted illnesses? The CDC’s answer is yes. A review of 83 studies published from the Journal Contraception in 2006 found that combined oral contraceptives and Depo-Provera use generally had a positive association with cervical chlamydial infection. Chlamydia infection and other inflammatory STDs these as Syphilis or genital Herpes are reported by the CDC to increase the risk of transmission of Human Immunodeficiency Virus infection. Chlamydia is well known as the leading preventable infection that can result in a severe condition called Pelvic Inflammatory Disorder, which, if not treated, can result in female infertility.
The recent STD report for 2008 from the CDC states that adolescent girls among the ages of 15-19 account for 27 per cent of the total new instances of chlamydia and gonorrhea. While acknowledging that adolescent boys have a similar prevalence of STDs,
microsoft Office 2010 Serial, the CDC insisted that because of “biological differences” young females have a greater potential to suffer consequences to their well being than young males.
Depressing intercourse
Yet, what was most surprising to Dr Meg Meeker, pediatrician and adolescent medication specialist, was her observation that many of her adolescent girl patients who had begun to engage in ######ual encounters had been showing signs of clinical depression. In her book, Strong Fathers, Strong Daughters (2007), she says: “Kids get depressed when they experience a loss for which they cannot express a healthy emotion. This is very common with ######ual activity. When a girl has ######, she loses her virginity and very often loses her self-respect with it”.
That clinical observation of a single pediatrician is supported by findings of researchers interested in any association amongst teenage ######ual experimentation, drug use and depression. Denise Hallfors and colleagues found that for girls even modest involvement in ######ual experimentation or substance use elevated depression risk. In contrast, boys exhibited little added risk of depression with ######ual experimental behavior, although binge drinking and frequent use of marijuana contribute substantial risk.
Thanatos syndrome revisited
In Walker Percy’s 1987 novel, The Thanatos Syndrome, Dr Tom More returns to his home town and family to restart what stays of his practice of psychiatry after serving a felony conviction for selling prescriptions for narcotics. After a few weeks of re-establishing contact with some of his former patients, he notices a profound change in his patients, with unusual mood changes, increased ability to recall the location of obscure names of places and the ability to make complex numeric calculations. In addition his patients all seem to have become hyper-eroticized, exhibiting outlandish ######ual advances that persons with intact higher-order self-control would recognize as outside the range of socially acceptable behavior.
He postulates something has changed his patients. With the help of an epidemiologist, More learns that toxic, radioactive sodium has been released from a nearby nuclear power plant and that the h2o with the heavy sodium is being deliberately channeled through an unauthorized and hidden pipe into the drinking water supply. Behind this scheme are some of More’s health-related colleagues, who discovered,
Windows 7 License, that dosing the drinking water supply with low concentrations of heavy sodium had the effect of suppressing the cognitive functioning of antisocial types like alcoholics, drug addicts, prostitutes or those confined to the local jail. The docs feel justified in what they are doing. They want Dr Tom to join them when they discover he knows what they are up to. Dr Tom knows better.
It appears that for the last 50 years,
Office Pro 2007 Key, something similar has been happening to America. The contraceptive pill was sold as the scientific panacea for ultimate ######ual liberation. Its real-time effect has been a form of “lobotomy” of reason and good judgement,
Windows 7 Pro Key, both of users and prescribers. It is time the healthcare establishment recognized its complicity and returned to that simple principle for which it gained the enviable respect and autonomy of action it merited as the premier profession that advocated for the unprotected and unknowing: “Above all, do no harm.”
Robert F. Conkling MD practices family medicine in Virginia and is co-founder of FertilityCare of the Capitol Region.
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