The urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae.
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Exposure to irinotecan and its active metabolite SN-38 is substantially reduced in adult and pediatric patients concomitantly receiving the CYP3A4 enzyme-inducing anticonvulsants phenytoin, phenobarbital or carbamazepine.
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Media type: IllustrationMedia file 2: Longitudinal section of the penis and its relationship to the bladder and the urethra.
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Do not use cotton swabs to probe or clean the ear canals.